Parasympathetic stimulation improves epithelial organ regeneration
نویسندگان
چکیده
منابع مشابه
Parasympathetic stimulation improves epithelial organ regeneration
Parasympathetic nerves are a vital component of the progenitor cell niche during development, maintaining a pool of progenitors for organogenesis. Injured adult organs do not regenerate after parasympathectomy, and there are few treatments to improve organ regeneration, particularly after damage by therapeutic irradiation. Here we show that restoring parasympathetic function with the neurotroph...
متن کاملBurn-Induced Organ Dysfunction: Vagus Nerve Stimulation Improves Cardiac Function
INTRODUCTION Many studies have demonstrated the existence of an anti-inflammatory, parasympathetic pathway, termed as the inflammatory reflex. Burn-induced heart failure has been investigated in many previous studies. Proinflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, have been shown to play a key pathogenetic role and vagus nerve stimulation attenuates proinflammatory cytokine p...
متن کاملElectro-stimulation of cerebellar fastigial nucleus (FNS) improves axonal regeneration.
This study focused on the effect of electro-stimulation of fastigial nucleus on the expression of NgR and on axonal regeneration after focal cerebral ischemia-reperfusion in rats. Cerebral ischemia and reperfusion was induced by nylon monofilament. Ninety-six male SD rats were randomly divided into sham group and ischemic insult groups at 12 hours, 24 hours, and 1 to 3 weeks after cerebral isch...
متن کاملOrgan Regeneration
Technologies for reprogramming cells are spreading like wildfire. One laboratory after another is reporting faster, more efficientmethods for generating cardiomyocytes, blood cells, and even neurons, all from readily available skin fibroblasts. But how close are these ‘‘custom-made’’ cells to reaching the clinic? This Select highlights recent studies demonstrating the ability of cultured stem c...
متن کاملGamma Interferon Induced Organ Regeneration
The salamander is the only vertebrate that has a substantial capacity to regenerate severed limbs and damaged organs. A necessary condition for this response is the lack of scar formation (fibrosis) at the site of injury. I postulate that suprapharmacologic doses of gamma interferon administered locally to the site of traumatic injury or disease induced organ capacity loss might unlock regenera...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2013
ISSN: 2041-1723
DOI: 10.1038/ncomms2493